If you have pain on the thumb side of the wrist that is worse with grasping and twisting motions of the wrist you may have DeQeurvain’s tenosynovitis. The pain may be associated with swelling, popping of the tendons with thumb motion and/or irritation of the nerve overlying the tendon leading to numbness over the back of the thumb and index finger.
DeQuervain's Tendonitis - Cause and Effects
Tendons that cause extension of the thumb pass through a tunnel along the thumb side of the wrist. Occasionally, the covering of these tendons that allow motion through the tunnel become inflamed. This inflammation causes pain with motion of the thumb as the tendons guide through the tunnel. The pain is worse with gripping, pinching, making a fist and turning the wrist.